The correct answer is Option 1) i.e. in, ofLet's take the second blank first, we have two choices die of/from, traditionally, 'die of' refers to dying as the result of a disease, and 'die from' refers to death as a result of an external cause such as an accident or a disaster.For example:My uncle died of cancer.She died of old age.He died from starvation. Therefore, 'of' is the best fit for the second blank and as a result, we can easily negate option 3 and 4. Now we are left with two choices for the first blank. 'In' here is the most appropriate as per the context of the sentence, 'from' is used to indicate the source or provenance of someone or something and 'accident' is neither a source or a medium it is an unfortunate event.Complete Sentence: The untimely loss of life is a cause of serious global concern as thousands of people get killed in accidents every year while many other die of diseases like cardiovascular disease, cancer, etc